Application of a Combined Aggregate Exposure Pathway and Adverse Outcome Pathway (AEP-AOP) Approach to Inform a Cumulative Risk Assessment: A Case Study with Phthalates

Identifying Qualitative Differences in PPARα Signaling Networks in Human and Rat Hepatocytes and Their Significance for Next Generation Chemical Risk Assessment Methods

The Role of Fit-For-Purpose Assays Within Tiered Testing Approaches

Workshop on the Validation and Regulatory Acceptance of Innovative 3R Approaches in Regulatory Toxicology

Addressing Systematic Inconsistencies Between in Vitro and in Vivo Transcriptomic Mode of Action Signatures

An Evaluation of the USEPA Proposed Approaches for Applying a Biologically Based Dose-Response Model in a Risk Assessment for Perchlorate in Drinking Water

Dose-dependence of Chemical Carcinogenicity: Biological Mechanisms for Thresholds and Implications for Risk Assessment

Assessing Bioactivity-Exposure Profiles of Fruit and Vegetable Extracts in the BioMAP Profiling System

Developing Context Appropriate Toxicity Testing Approaches Using New Alternative Methods (NAMs)

A Qualitative Modeling Approach for Whole Genome Prediction Using High-Throughput Toxicogenomics Data and Pathway-Based Validation

An in Vitro Approach for Prioritization and Evaluation of Chemical Effects on Glucocorticoid Receptor Mediated Adipogenesis

Evaluating Opportunities for Advancing the Use of Alternative Methods in Risk Assessment Through the Development of Fit-For-Purpose in Vitro Assays

Multiple Receptors Shape the Estrogen Response Pathway and Are Critical Considerations for the Future of in Vitro-Based Risk Assessment Efforts

Contribution of ATM and ATR Kinase Pathways to p53-mediated Response in Etoposide and Methyl Methanesulfonate Induced DNA Damage

Editor's Highlight: Screening ToxCast Prioritized Chemicals for PPARG Function in a Human Adipose-Derived Stem Cell Model of Adipogenesis

Editor's Highlight: Development of an In Vitro Assay Measuring Uterine-Specific Estrogenic Responses for Use in Chemical Safety Assessment

Moving Beyond Prioritization Toward True In Vitro Safety Assessment

Pathway Based Toxicology and Fit-for-Purpose Assays

Approaches for Characterizing Threshold Dose-Response Relationships for DNA-damage Pathways Involved in Carcinogenicity in Vivo and Micronuclei Formation in Vitro

Contributions of DNA Repair and Damage Response Pathways to the Non-Linear Genotoxic Responses of Alkylating Agents

Suppression of NRF2-ARE Activity Sensitizes Chemotherapeutic Agent-Induced Cytotoxicity in Human Acute Monocytic Leukemia Cells

Adaptive Posttranslational Control in Cellular Stress Response Pathways and Its Relationship to Toxicity Testing and Safety Assessment

Implementing Toxicity Testing in the 21st Century (TT21C): Making Safety Decisions Using Toxicity Pathways, and Progress in a Prototype Risk Assessment

Development of a Human Adipose-derived Stem Cell Model for Characterization of Chemical Modulation of Adipogenesis

Profiling Dose-Dependent Activation of p53-mediated Signaling Pathways by Chemicals With Distinct Mechanisms of DNA Damage

Use of Mode of Action Data to Inform a Dose-Response Assessment for Bladder Cancer Following Exposure to Inorganic Arsenic

A Map of the PPARα Transcription Regulatory Network for Primary Human Hepatocytes

Dose-response Modeling of Etoposide-Induced DNA Damage Response

Keap1 Silencing Boosts Lipopolysaccharide-Induced Transcription of Interleukin 6 via Activation of Nuclear Factor κB in Macrophages

Assessing Dose-Dependent Differences in DNA-damage, p53 Response and Genotoxicity for Quercetin and Curcumin

Evaluation of a Predictive in Vitro Leydig Cell Assay for Anti-Androgenicity of Phthalate Esters in the Rat

Mechanism-based Testing Strategy Using in Vitro Approaches for Identification of Thyroid Hormone Disrupting Chemicals

A Dose Response Study to Assess Effects After Dietary Administration of Diisononyl Phthalate (DINP) in Gestation and Lactation on Male Rat Sexual Development

Disposition of Diiosononyl Phthalate and Its Effects on Sexual Development of the Male Fetus Following Repeated Dosing in Pregnant Rats

In Vitro Metabolism of Di(2-ethylhexyl) Phthalate (DEHP) by Various Tissues and Cytochrome P450s of Human and Rat

Physiologically Based Pharmacokinetic/Toxicokinetic Modeling. In: Methods in Molecular Biology,

Challenges in the Application of Quantitative Approaches in Risk Assessment: A Case Study With Di-(2-ethylhexyl)phthalate

Assessing the Relevance of in Vitro Measures of Phthalate Inhibition of Steroidogenesis for in Vivo Response

In Utero Exposure to Chloroquine Alters Sexual Development in the Male Fetal Rat

Kinetics of Selected Di-N-Butyl Phthalate Metabolites and Fetal Testosterone Following Repeated and Single Administration in Pregnant Rats

Tissue Exposures to Free and Glucuronidated Monobutylyphthalate in the Pregnant and Fetal Rat Following Exposure to Di-N-Butylphthalate: Evaluation With a PBPK Model

Development and Specification of Physiologically Based Pharmacokinetic Models for Use in Risk Assessment

Perchlorate and Radioiodide Kinetics Across Life Stages in the Human: Using PBPK Models to Predict Dosimetry and Thyroid Inhibition and Sensitive Subpopulations Based on Developmental Stage

PBPK Model for Radioactive Iodide and Perchlorate Kinetics and Perchlorate-Induced Inhibition of Iodide Uptake in Humans

Evidence for Competitive Inhibition of Iodide Uptake by Perchlorate and Translocation of Perchlorate Into the Thyroid

Predicting Neonatal Perchlorate Dose and Inhibition of Iodide Uptake in the Rat During Lactation Using Physiologically-Based Pharmacokinetic Modeling

Predicting Fetal Perchlorate Dose and Inhibition of Iodide Kinetics During Gestation: A Physiologically-Based Pharmacokinetic Analysis of Perchlorate and Iodide Kinetics in the Rat

PBPK Predictions of Perchlorate Distribution and Its Effect on Thyroid Uptake of Radioiodide in the Male Rat

Pharmacokinetics of Toxic Chemicals in Breast Milk: Use of PBPK Models to Predict Infant Exposure

The Use of Physiologically Based Models to Integrate Diverse Data Sets and Reduce Uncertainty in the Prediction of Perchlorate and Iodide Kinetics Across Life Stages and Species