Areas of Expertise
COMPUTATIONAL TOXICOLOGY
In silico approaches for interpreting mode of action, dose-response and chemical prioritization.
IN VITRO
TOXICOLOGY
High throughput and organotypic in vitro tests for mode of action, dose-response, and human relevance.
IN VIVO
TOXICOLOGY
Design and interpretation of studies that promote the 3Rs: refinement, reduction and replacement.
About Rebecca Clewell
Dr. Clewell is an internationally recognized expert on the development of in vitro and computational tools to support chemical safety decisions. Bringing together 20 years of experience in quantitative biology and chemical dose-response, Dr. Clewell conducts research and designs testing strategies that maximize the use of New Approach Methods in determining chemical mode of action and dose-response to support quantitative risk-based decisions.
READ MORESelect Research Publications
VIEW ALLAug 2020
Application of a Combined Aggregate Exposure Pathway and Adverse Outcome Pathway (AEP-AOP) Approach to Inform a Cumulative Risk Assessment: A Case Study with Phthalates
VIEW ABSTRACTApr 2020
Identifying Qualitative Differences in PPARα Signaling Networks in Human and Rat Hepatocytes and Their Significance for Next Generation Chemical Risk Assessment Methods
VIEW ABSTRACTSep 2019
Workshop on the Validation and Regulatory Acceptance of Innovative 3R Approaches in Regulatory Toxicology
VIEW ABSTRACTAug 2019
Addressing Systematic Inconsistencies Between in Vitro and in Vivo Transcriptomic Mode of Action Signatures
VIEW ABSTRACTApr 2019
An Evaluation of the USEPA Proposed Approaches for Applying a Biologically Based Dose-Response Model in a Risk Assessment for Perchlorate in Drinking Water
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